Table 1.
Phosphorylation of selected kinases in ArKO and WT female mice
| Kinase: Phosphorylation site | Fold change ArKO/WT |
|---|---|
| Lower in ArKO | |
| P53: S392 | 0.52 |
| TOR: S2448 | 0.69 |
| c-Jun: S63 | 0.71 |
| HSP27: S78/S82 | 0.74 |
| p70 S6 kinase: T229 | 0.74 |
| PLCγ-1: Y783 | 0.79 |
| Unchanged in ArKO | |
| STAT4: Y693 | 0.81 |
| ERK1/2: T202/Y204, T185/Y187 | 0.83 |
| Src: Y419 | 0.89 |
| RSK1/2: S221 | 0.92 |
| Paxillin: Y118 | 0.93 |
| MSK1/2: S376/S360 | 0.97 |
| Pyk2: Y402 | 0.97 |
| MEK1/2: S218/S222 | 1.00 |
| P70 S6 kinase: T421/S424 | 1.02 |
| Hck: Y411 | 1.06 |
| STAT1: Y701 | 1.09 |
| STAT2: Y689 | 1.11 |
| eNOS: S1177 | 1.12 |
| Lyn: Y397 | 1.13 |
| P53: S15 | 1.15 |
| Yes: Y426 | 1.18 |
| Higher in ArKO | |
| Akt: Thr308 | 1.21 |
| P53: S46 | 1.22 |
| RSK1/2/3: S380 | 1.22 |
| P27: T157 | 1.23 |
| STAT5a/b: Y699 | 1.24 |
| STAT5b: Y699 | 1.28 |
| Chk-2: T68 | 1.36 |
| AMPKα2: T172 | 1.38 |
| STAT6: Y641 | 1.39 |
| CREB: S133 | 1.47 |
| β-Catenin | 1.52 |
| STAT5a: Y699 | 1.65 |
| P27: T198 | 1.74 |
| P38α: T180/Y182 | 1.77 |
| Fgr: Y412 | 2.79 |
| GSK-3α/&β: S21/S9 | 2.94 |
| Akt: Ser473 | 3.23 |
| FAK: Y397 | 3.73 |
| JNK pan: T183/Y185, T221/Y223 | 3.85 |
| Ampka1: T174 | 5.10 |
| STAT3: Y705 | 5.73 |
| Fyn: Y420 | 8.77 |
CREB, cAMP response element-binding protein; AMPKα2, AMP-activated protein kinase catalytic subunit 2.