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. 2012 Jul 20;153(9):4181–4191. doi: 10.1210/en.2012-1541

Fig. 3.

Fig. 3.

Enhanced jejunal fructose uptake in HFrD-fed GLUT8KO mice. A, Enhanced baseline and HFrD-stimulated jejunal fructose uptake in GLUT8KO mice. WT and GLUT8KO mice were fed chow or HFrD for 5 d, and [14C]-fructose uptake was measured. *, P < 0.001 vs. chow-fed WT group; **, P < 0.05 vs. HFrD-fed WT group. B, Increased serum fructose excursion in GLUT8KO mice. WT and GLUT8KO mice were fasted overnight and orally gavaged with unlabeled fructose. Shown is the mean serum fructose concentration at each time point. C, GLUT8 deficiency does not alter baseline or fructose diet-stimulated jejunal 2DG uptake. WT and GLUT8KO mice were fed chow or HFrD for 5 d, killed, and [3H]-2DG uptake in resected jejunal rings was measured. Bars represent pooled mean 2DG uptake from two experiments, n = 10–15 rings per group. P = Not significant for chow-fed GLUT8KO vs. chow-fed WT and for HFrD-fed GLUT8KO vs. HFrD-fed WT groups.