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. 2012 Jul 20;153(9):4181–4191. doi: 10.1210/en.2012-1541

Fig. 6.

Fig. 6.

Exacerbated fasting hyperinsulinemia, hyperlipidemia, and relative hypertension in GLUT8KO mice (G8KO). A, WT and GLUT8KO mice were maintained on chow or on HFrD for 18 wk and fasted overnight. Serum was collected, and insulin was measured as in experimental procedures. Shown is the mean insulin concentration ± se for n = 5–8 mice in each group. *, P < 0.05 vs. WT HFrD group. B and C, Exacerbated hyperlipidemia in HFrD-fed GLUT8KO mice. Graphed in B and C are the mean total cholesterol and calculated LDL concentrations, respectively, for chow- and HFrD-fed WT and GLUT8KO mice. n = 9–11 mice per group. *, P < 0.05 vs. WT chow-fed group; **, P < 0.05 vs. HFrD-fed WT group. D, Enhanced blood pressure elevation in response to chronic high-fructose feeding in GLUT8KO mice. Mice were fed chow or HFrD for 24 wk and subjected to tail-cuff plethysmography. Graphed is the mean percent change in systolic (left) or diastolic (right) pressure vs. chow-fed control mice ± se; n = from 9–11 mice, each with more than or equal to three readings per mouse per group.