Fig. 7.

Schematic representing AAT immune cell differences at 20 and 26 wk. At 20 wk, although more T cells are present in the AAT of OVX mice, no differences in insulin sensitivity exist. By 26 wk, although OVX and SHM mice remain equivalent in terms of obesity and adipose tissue mass/distribution, OVX mice are less insulin sensitive than SHM mice, which coincides with T cell and MΦ cross-activation as illustrated by greater gene expression of IL12p40, which is secreted by activated T cells, and IFN-γ, which is secreted by activated MΦ bearing the marker CD11c.