Table 2.
Protein modification and degradation
| UniProt Gene ID | UniProt accession no. | Protein name | log2 (p53d/d/p53f/f) | P value |
|---|---|---|---|---|
| Posttranslational modification | ||||
| Calu | O35887 | Calumenin | −0.486 | 7.4E-06 |
| Man2a1 | P27046 | α-Mannosidase 2 | p53f/f onlyb | — |
| Padi2 | Q08642 | Protein-arginine deiminase type-2 | p53f/f onlyb | — |
| Pdia6 | Q922R8 | Protein disulfide-isomerase A6a | −1.284 | 2.3E-03 |
| Rpn1 | Q91YQ5 | Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 1 | −0.739 | 1.4E-05 |
| Rpn2 | Q9DBG6 | Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 2a | −0.702 | 2.5E-03 |
| Sptlc2 | P97363 | Serine palmitoyltransferase 2 | −0.741 | 2.9E-03 |
| Tgm2 | P21981 | Protein-glutamine γ-glutamyltransferase 2a | −0.609 | 3.9E-04 |
| Fkbp5 | Q64378 | Peptidyl-prolyl cis-trans isomerase FKBP5 | −0.810 | 3.6E-06 |
| Fkbp1a | P26883 | Peptidyl-prolyl cis-trans isomerase FKBP1Aa | 0.610 | 1.0E-03 |
| Fkbp4 | P30416 | Peptidyl-prolyl cis-trans isomerase FKBP4a | 0.757 | 8.9E-04 |
| Proteasome and related proteins | ||||
| Cand1 | Q6ZQ38 | Cullin-associated NEDD8-dissociated protein 1 | 0.440 | 5.6E-04 |
| Ecm29 | Q6PDI5 | Proteasome-associated protein ECM29 homolog | 0.493 | 3.7E-03 |
| Psmd1 | Q3TXS7 | 26S proteasome non-ATPase regulatory subunit 1 | p53d/d onlyc | — |
| Psmd12 | Q9D8W5 | 26S proteasome non-ATPase regulatory subunit 12a | 0.283 | 1.3E-03 |
| Psmd2 | Q8VDM4 | 26S proteasome non-ATPase regulatory subunit 2 | 0.490 | 2.8E-03 |
| Psmd3 | P14685 | 26S proteasome non-ATPase regulatory subunit 3 | 0.474 | 1.3E-04 |
| Psmd8 | Q9CX56 | 26S proteasome non-ATPase regulatory subunit 8 | 0.483 | 1.0E-03 |
| Psme3 | P61290 | Proteasome activator complex subunit 3 | 0.390 | 8.3E-04 |
| Trim28 | Q62318 | Transcription intermediary factor 1-βa | 0.441 | 1.6E-03 |
| Uba1 | Q02053 | Ubiquitin-like modifier-activating enzyme 1 | 0.474 | 7.6E-04 |
| Ubc | Q9Z0H9 | Ubiquitin | 0.933 | 2.6E-03 |
| Psma1 | Q9R1P4 | Proteasome subunit α type-1 | −1.641 | 4.1E-03 |
| Ubqln2 | Q9QZM0 | Ubiquilin-2 | p53f/f onlyb | — |
| Usp14 | Q9JMA1 | Ubiquitin carboxyl-terminal hydrolase 14 | p53f/f onlyb | — |
| Proteinases | ||||
| Clpp | O88696 | Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial | −0.553 | 4.9E-04 |
| Dpep1 | P31428 | Dipeptidase 1 | −0.939 | 1.6E-03 |
| Gzmb | P04187 | Granzyme B(G,H)a | −0.903 | 1.7E-03 |
| Thop1 | Q8C1A5 | Thimet oligopeptidase | −1.111 | 2.6E-03 |
| Spcs2 | Q9CYN2 | Signal peptidase complex subunit 2 | −0.553 | 8.9E-04 |
| Xpnpep1 | Q6P1B1 | Xaa-Pro aminopeptidase 1 | −0.443 | 1.3E-05 |
| Capns1 | O88456 | Calpain small subunit 1 | 0.703 | 2.4E-03 |
| Npepps | Q11011 | Puromycin-sensitive aminopeptidase | 0.195 | 2.6E-03 |
| Scpep1 | Q920A5 | Retinoid-inducible serine carboxypeptidasea | 0.592 | 6.6E-04 |
| Proteinases inhibitors | ||||
| A2mp | Q6GQT1 | α-2-Macroglobulin-Pa | −1.999 | 7.7E-13 |
| Cstb | Q62426 | Cystatin-Ba | −1.000 | 1.0E-03 |
| Serpina3k | P07759 | Serine protease inhibitor A3K | −1.109 | 4.6E-04 |
| Serpinb6 | Q60854 | Serpin B6a | −0.391 | 7.1E-04 |
| Serpinc1 | P32261 | Antithrombin-III | −0.459 | 2.0E-05 |
a
Characterized by IMS-MS and Velos instruments (average values used for fold change and P values).
b
p53f/f only, p53d/d samples do not show any signal.
c
p53d/d only, p53f/f samples do not show any signal.