Table 3.
Metabolism
| UniProt Gene ID | UniProt accession no. | Protein name | log2 (p53d/d/p53f/f) | P value |
|---|---|---|---|---|
| Lipid metabolism and related proteins | ||||
| Acot11 | Q8VHQ9 | Acyl-coenzyme A thioesterase 11 | −0.701 | 1.8E-04 |
| Ech1 | O35459 | δ(3,5)-δ(2,4)-dienoyl-CoA isomerase, mitochondrial | −0.654 | 2.3E-03 |
| Pafah1b2 | Q61206 | Platelet-activating factor acetylhydrolase IB subunit βa | −0.605 | 2.7E-04 |
| Psap | Q61207 | Sulfated glycoprotein 1a | −0.622 | 5.7E-05 |
| Sgpl1 | Q8R0 × 7 | Sphingosine-1-phosphate lyase 1a | −0.533 | 1.6E-04 |
| Apoa1 | Q00623 | Apolipoprotein A-Ia | 0.672 | 1.4E-03 |
| Apoe | P08226 | Apolipoprotein E | 0.952 | 6.9E-04 |
| Mitochondrial ATP production (fatty acid β-oxidation) | ||||
| Acaa2 | Q8BWT1 | 3-Ketoacyl-CoA thiolase, mitochondriala | −0.698 | 1.8E-06 |
| Acadvl | P50544 | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial | −0.515 | 2.9E-03 |
| Dbi | P31786 | Acyl-CoA-binding proteina | −0.538 | 2.5E-04 |
| Hadh | Q61425 | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | −0.725 | 4.6E-03 |
| Hadha | Q8BMS1 | Trifunctional enzyme subunit α, mitochondrial | p53f/f onlyb | — |
| Hadhb | Q99JY0 | Trifunctional enzyme subunit β, mitochondrial | −0.724 | 2.3E-03 |
| Mitochondrial ATP production (electron transport chain) | ||||
| Atp5c1 | Q91VR2 | ATP synthase subunit γ, mitochondrial | −0.568 | 2.4E-04 |
| Atp5i | Q06185 | ATP synthase subunit e, mitochondrial | −0.417 | 1.0E-03 |
| Cox5b | P19536 | Cytochrome c oxidase subunit 5B, mitochondriala | −1.105 | 2.6E-03 |
| Cox7a2 | P48771 | Cytochrome c oxidase subunit 7A2, mitochondrial | −0.609 | 3.8E-05 |
| Cyb5a | P56395 | Cytochrome b5 | −0.931 | 3.9E-05 |
| Etfa | Q99LC5 | Electron transfer flavoprotein subunit α, mitochondrial | −0.327 | 5.1E-04 |
| Mtco2 | P00405 | Cytochrome c oxidase subunit 2 | p53f/f onlyb | — |
| Mtnd5 | P03921 | NADH-ubiquinone oxidoreductase chain 5 | −0.837 | 1.9E-03 |
| Cisd1 | Q91WS0 | CDGSH iron sulfur domain-containing protein 1 | 0.622 | 4.7E-03 |
| Mitochondrial ATP production (tricarboxylic acid cycle) | ||||
| Aco2 | Q99KI0 | Aconitate hydratase, mitochondrial | −0.597 | 1.7E-03 |
| Dld | O08749 | Dihydrolipoyl dehydrogenase, mitochondrial | −0.857 | 2.3E-03 |
| Idh1 | O88844 | Isocitrate dehydrogenase (NADP) cytoplasmica | −0.635 | 9.4E-04 |
| Idh2 | P54071 | Isocitrate dehydrogenase (NADP), mitochondriala | −0.716 | 2.7E-03 |
| Idh3g | P70404 | Isocitrate dehydrogenase (NAD) subunit-γ, mitochondrial | −0.809 | 2.7E-03 |
| Mdh2 | P08249 | Malate dehydrogenase, mitochondrial | −0.532 | 4.7E-05 |
| Suclg1 | Q9WUM5 | Succinyl-CoA ligase (GDP-forming) subunit α, mitochondrial | −1.231 | 1.6E-03 |
| Other metabolism | ||||
| Acat1 | Q8QZT1 | Acetyl-CoA acetyltransferase, mitochondrial | −0.609 | 2.3E-03 |
| Adh5 | P28474 | Alcohol dehydrogenase class-3 | −0.398 | 1.3E-04 |
| Akr1b1 | P45376 | Aldose reductase | −1.016 | 3.0E-03 |
| Aldh9a1 | Q9JLJ2 | 4-Trimethylaminobutyraldehyde dehydrogenase | −0.661 | 1.6E-03 |
| Asl | Q91YI0 | Argininosuccinate lyasea | −0.693 | 3.4E-05 |
| Ckb | Q04447 | Creatine kinase B-type | −0.713 | 2.9E-03 |
| Cyb5r3 | Q9DCN2 | NADH-cytochrome b5 reductase 3 | −0.378 | 2.8E-03 |
| Dck | P43346 | Deoxycytidine kinase | −0.836 | 3.6E-03 |
| Dhcr24 | Q8VCH6 | 24-Dehydrocholesterol reductasea | −0.888 | 1.9E-05 |
| Es1 | P23953 | Liver carboxylesterase Na | −0.781 | 1.0E-04 |
| Gatm | Q9D964 | Glycine amidinotransferase, mitochondriala | −0.499 | 5.1E-04 |
| Gda | Q9R111 | Guanine deaminase | −0.961 | 4.1E-04 |
| Glul | P15105 | Glutamine synthetasea | −0.953 | 2.9E-04 |
| Mpi | Q924M7 | Mannose-6-phosphate isomerasea | −0.495 | 3.3E-04 |
| Nampt | Q99KQ4 | Nicotinamide phosphoribosyltransferase | −0.300 | 2.4E-04 |
| Nudt5 | Q9JKX6 | ADP-sugar pyrophosphatasea | −0.404 | 4.4E-04 |
| Oat | P29758 | Ornithine aminotransferase, mitochondrial | −1.362 | 3.3E-03 |
| Pik3c3 | Q6PF93 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | −0.754 | 2.4E-03 |
| Ahcy | P50247 | Adenosylhomocysteinase | 0.220 | 1.8E-04 |
| Ak1 | Q9R0Y5 | Adenylate kinase isoenzyme 1a | 0.687 | 1.1E-04 |
| Aldh1a2 | Q62148 | Retinal dehydrogenase 2 | 0.601 | 2.0E-05 |
| Fmo1 | P50285 | Dimethylaniline monooxygenase (N-oxide-forming) 1 | 1.227 | 3.8E-03 |
| Gc | P21614 | Vitamin D-binding protein | 0.872 | 1.7E-03 |
| Gpd1l | Q3ULJ0 | Glycerol-3-phosphate dehydrogenase 1-like protein | 0.373 | 3.6E-03 |
| Hdlbp | Q8VDJ3 | Vigilin | 0.374 | 2.5E-03 |
| Prpsap1 | Q9D0M1 | Phosphoribosyl pyrophosphate synthase-associated protein 1 | 0.463 | 1.5E-03 |
| Sqrdl | Q9R112 | Sulfide:quinone oxidoreductase, mitochondriala | 0.800 | 5.0E-07 |
| Tdo2 | P48776 | Tryptophan 2,3-dioxygenasea | 0.455 | 2.6E-03 |
| Umps | P13439 | Uridine 5′-monophosphate synthase | 0.532 | 1.3E-04 |
a
Characterized by IMS-MS and Velos instruments (average values used for fold change and P values).
b
p53f/f only, p53d/d samples do not show any signal.