Table 1.

Endocrinology and the BBB: examples of disease associations

Disease/condition	Contribution	References
Obesity	Defective blood-to-brain transport of leptin	(131)
Diabetes mellitus	Disruption of the BBB	(132)
Hypertensive urgency/emergency	Angiotensin II induction of macropinocytosis at BEC	(66)
Baroreceptor deficiency in pregnancy	Decreased insulin in CNS	(59)
Alzheimer's disease	Insulin resistance in brain	(125)
Fever (sickness behavior)	Prostaglandin secretion in response to IL-1	(133)