Fig. 2.

Macrophage accumulation into the neointima strongly correlates with plasma cholesterol and TA severity. (A) Representative micrographs of macrophage-specific CD68 staining of arterial allograft sections collected from wt, ApoE^−/− and ApoE^−/−HFD recipients. (B) Macrophage accumulation in aortic allografts harvested from wt (n = 5), ApoE^−/− (n = 9) and ApoE^−/−HFD (n = 7) hosts, expressed as percentage of the neointimal area. Macrophage recruitment is significantly increased in mice with high plasma cholesterol levels (C) (R² = 0.847, P < 0.001) and correlates well with disease severity (D) (R² = 0.751, P < 0.001). ** P < 0.01 *** P < 0.001.