Fig. 3.

T cell depletion does not influence macrophage accumulation into the neointima. Quantification of CD4 T cell infiltration into allografts harvested from the normolipidemic wt (n = 5) and hyperlipidemic ApoE^−/−HFD (n = 7) mice expressed as total number of infiltrating cells per section (A) and as number of cells reported to the area of the lesion (B). (C, D) Lesion development and macrophage recruitment in allografts harvested from ApoE^−/−HFD recipients treated with depleting anti-CD4 and anti-CD8 antibodies (n = 6) compared to a rat IgG control group (n = 6). * P < 0.05, *** P < 0.001. HFD, high fat diet.