Table 2.
Risk of Colorectal Cancer by Exposure to Selected Infections
| Infection | Infection Na | Cancer N (%) | Hazard ratio (95% CI)b | p value |
|---|---|---|---|---|
| No selected infectionc | 364,324 | 258 (0.07) | 1.00 | |
| Any selected infectionc | 107,426 | 62 (0.06) | 1.23 (0.92–1.64) | 0.168 |
| Esophageal candidiasis | 42,216 | 28 (0.07) | 1.34 (0.90–1.98) | 0.147 |
| Mycobacterium avium complex | 22,351 | 6 (0.03) | 0.77 (0.29–2.07) | 0.603 |
| Mucocutaneous herpes | 14,351 | 15 (0.10) | 1.69 (0.97–2.95) | 0.066 |
| Cytomegalovirus, systemic | 14,127 | 5 (0.04) | 1.03 (0.42–2.49) | 0.952 |
| Cryptococcosis, extrapulmonary | 13,884 | 4 (0.03) | 0.74 (0.27–1.98) | 0.542 |
| Extrapulmonary tuberculosis | 8,737 | 7 (0.08) | 1.60 (0.75–3.40) | 0.222 |
| Cryptosporidiosis | 7,978 | 7 (0.09) | 2.08 (0.93–4.70) | 0.077 |
| Atypical mycobacterium | 4,633 | 2 (0.04) | 1.03 (0.26–4.15) | 0.965 |
| Salmonella septicemia | 933 | 1 (0.11) | 2.10 (0.29–14.96) | 0.461 |
| Coccidioidomycosis | 587 | 0 (0.00) | — | 0.958 |
| Pneumocystis pneumonia | 117,373 | 48 (0.04) | 0.79 (0.57–1.10) | 0.167 |
Cancers occurred within risk period of 4 to 120 months after AIDS diagnosis.
a
Infections are not mutually exclusive.
b
Models were run separately for each condition and adjusted for age, sex, race, mode of HIV acquisition, CD4 count, and AIDS diagnosis year.
c
Selected infections are listed as those that may involve the colorectum, excluding pneumocystis pneumonia.