Table 3.
Risk of Colorectal Cancer Following Cryptosporidiosis and Mucocutaneous Herpes by Histology and Anatomic Site
| |
|
Cryptosporidiosis |
Mucocutaneous herpes |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Cancer N | N | Unadjusted HR (95% CI)a | Adjusted HR (95% CI)a,b | p valuea,b | N | Unadjusted HR (95% CI)a | Adjusted HR (95% CI) | p valuea,b | |
| Cancer histology | |||||||||
| Adenocarcinoma | 269 | 3 | 1.0 (0.3–3.1) | 1.3 (0.4–3.9) | 0.70 | 10 | 1.0 (0.5–2.1) | 1.3 (0.6–2.6) | 0.52 |
| Squamous cell carcinoma | 8 | 1 | 13 (1.6–100) | 13 (1.5–110) | 0.02 | 2 | 11 (2.2–54) | 13 (2.4–67) | 0.003 |
| Otherc | 43 | 3 | 4.3 (1.0–18) | 4.4 (1.1–18) | 0.04 | 3 | 2.4 (0.7–7.8) | 2.5 (0.8–8.2) | 0.13 |
| Cancer site | |||||||||
| Proximal to rectosigmoid junction | 176 | 4 | 2.1 (0.8–5.6) | 2.3 (0.9–6.3) | 0.13 | 9 | 1.6 (0.8–3.2) | 1.9 (0.9–3.8) | 0.08 |
| Rectum/rectosigmoid junction | 144 | 3 | 1.2 (0.3–5.0) | 1.6 (0.4–6.6) | 0.50 | 6 | 1.2 (0.5–2.9) | 1.5 (0.6–3.6) | 0.42 |
a
Analyses were run separately for each intestinal infection condition and by each cancer subtype.
b
Models were adjusted for age, sex, race, mode of AIDS acquisition, CD4 count, and AIDS diagnosis year.
c
Other cancers include small cell carcinoma, leiomyosarcoma, and undifferentiated carcinoma.