Table 2.
Details of EGT treatment and response to therapy
| Pt No. | Nodule | Tumor volume before EGT (cm3) | Tumor volume after EGT1 (cm3) | No. of sessions | Dose of pIL12 per EGT session (mg) | Dose of plasmid per body weight (mg/kg)2 | Post EGT therapy | Follow up after 1st EGT (months) | Response at the end of follow up | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 | 0.25 | 0.1 | 2 | 0.15/0.15 | 0.05 | / | 36 | SD | Euth., not related to MCT |
| 2 | 1 | 2.3 | 2.0 | 1 | 0.5 | 0.01 | Surgery | 24 | CR | without recurrence |
| 3 | 1 | 3.2 | 1.6 | 2 | 1.0/1.0 | 0.12 | CCNU (4 cycles) | 12 | SD | stable disease |
| 4 | 1 | 0.6 | 0.3 | 2 | 0.5/0.2 | 0.06 | ECT | 13 | CR | without recurrence |
| 2 | 1.2 | 0.8 | 2 | 0.5/0.4 | Surgery | CR | without recurrence | |||
| 5 | 1 | 2.9 | 0.6 | 2 | 0.5/0.5 | 0.03 | Surgery | 10 | CR | without recurrence |
| 6 | 1 | 0.03 | 0.005 | 4 | 0.1/0.1/0.1/0.1 | 0.07 | / | 44 | SD | stable disease |
| 2 | 0.27 | 0.08 | 4 | 0.25/0.25/0.25/0.25 | / | SD | ||||
| 7 | 1 | 25.4 | 18.0 | 3 | 1.0/0.6/0.6 | 0.12 | Surgery | 2 | PD | Euth. due to PD |
| 8 | 1 | 0.45 | 0.6 | 1 | 0.2 | 0.025 | CCNU (3 cycles) | 5 | PD | Euth. due to PD |
| 2 | 0.03 | 0.03 | 1 | 0.1 | ||||||
Euth, euthanasia; MCT, mast cell tumor; CR, complete response; CCNU, lomustine; ECT, electrochemotherapy; SD, stable disease; PD, progressive disease
1
The smallest volume of tumor nodule, achieved 1 week after the last performed EGT session
2
Cumulative dose of received plasmid per kg of body weight