Skip to main content
. 2012 Jun 1;120(7):1489–1498. doi: 10.1182/blood-2012-01-404046

Figure 1.

Figure 1

Anti–Gr-1 blocks K/BxN serum transfer arthritis at nondepleting doses. (A) Mice were administered anti–Gr-1 intraperitoneally at various doses, followed by arthritogenic K/BxN serum as indicated. Data derived from 2-5 experiments (n = 7-21 mice/group, all P < .01 vs control by ANOVA). (B) Paw edema scored 30 minutes after injection of K/BxN serum. Neutrophil-dependent edema was suppressed only at high doses of anti–Gr-1. Data are presented from 7-21 mice per condition as described in panel A. Control indicates PBS in 4 experiments. (C) Automated absolute neutrophil counts in blood from unmanipulated mice and mice killed on arthritis day 4. Animals treated twice with 10 μg of anti–Gr-1 exhibited lower neutrophil counts compared with control animals with inflamed joints, but similar numbers to noninflamed mice. *P < .05; ***P < .001.