Figure 8.

SB-334867 does not reduce cocaine-induced locomotor activity. Shown are the mean ± SEM of locomotor activity expressed as distance traveled (cm) for animals treated with i.p. vehicle (n = 26) or SB-334867 (7.5, 15, or 30 mg/kg n = 9). Left inset shows area under the curve (AUC) during the habituation period. Right inset shows AUC after i.p. injection of 10 mg/kg cocaine. During habituation, SB-334867 reduced locomotor activity but only for the highest dose tested (30 mg/kg). Following i.p. cocaine, however, SB-334867 had no significant effect on locomotor activity. Note that following cocaine injections, the 30 mg/kg SB-334867 group showed the highest amount of locomotor activity. ^*P < 0.05, relative to vehicle.