FIG. 6.

Quercetin attenuates the diabetes phenotype in FA mice. (A) Fanca+/+ and Fanca^−/− mice (3–4 months old, n=6–8 each group) were injected with Quercetin (50 mg/Kg) twice per week for 2 weeks. After the final injection, whole-blood glucose was measured in mice fasted overnight by using tail blood. The data are presented as mean±SD. *p<0.05 for Fanca^−/− mice versus Fanca+/+mice. (B, C) The mice as described in (A) were fasted and given an injection (IP) of either glucose (1 g/Kg of body weight) (B) or insulin (1.0 U/Kg of body weight) (C), and whole-blood glucose was examined at the indicated time points by using the glucometer. The results are shown as the percentage of the initial glucose levels. *p<0.05 for Fanca^−/− mice versus Fanca+/+mice, or Fanca^−/− mice injected with Quercetin versus those with vehicle. (D) Fanca+/+and Fanca^−/− mice (6–7 weeks old, n=6–8 each group) were fed with HFD and injected with Quercetin (50 mg/Kg) twice per week for 6 weeks. The weight was examined at the indicated time points of the Quercetin treatment. The results are shown as the original readout. *p<0.05 for Fanca^−/− fed with HFD without Quercetin treatment versus Fanca+/+mice.