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TAS2R activation is highly efficacious in relaxing ASM under conditions of β2AR desensitization. As described above in Fig. 4, intact mouse trachealis were studied before (Control) or after treatment with the β-agonist Iso (Post-Iso treatment). Subsequent Iso and Chloro responses were measured in rings contracted with ACh. Values are means ± SE (n = 4 experiments). *P < 0.01.
