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TAS2R activation dilates intact human small airways under conditions of β2AR desensitization. Human precision-cut lung slices (PCLSs) were incubated for 18 h in the absence (Control) or presence of long-acting β-agonist salmeterol (Post-Sal treatment), washed, and constricted with carbachol. Carbachol-constricted airways were treated sequentially with 1 μM Iso and 50 μM Chloro. Values are means ± SE (obtained using 102 PCLSs derived from 4 donors). *P < 0.005.
