Fig. 4.
A: changes in levels of miR-21 in lung homogenates from mice treated with negative control miR, anti-miR-21, or pre-miR-21 followed by mechanical HVTV for 4 h, compared with control mice: *P < 0.05 for all ventilated mice compared with control mice, #P < 0.05 for pre-miR-21 treatment vs. negative control miR, ^P < 0.05 for anti-miR-21 treatment vs. negative control miR. B: changes in levels of BMPR2 mRNA in lung homogenates from mice treated with negative control miR, anti-miR-21, or pre-miR-21 followed by HVTV for 4 h, compared with control mice: *P < 0.001 for negative-control-miR and pre-miR-21 treatment vs. control, and PTEN mRNA; *P < 0.001 for all ventilated mice vs. control, #P < 0.05 for anti-miR-21 treatment vs. negative-control-miR and pre-miR-21.