Fig. 5.
Evaluation of lung injury in mice treated with negative control miR, anti-miR-21, or pre-miR-21 followed by mechanical HVTV for 4 h, compared with control mice. All data are presented in whisker blots (min-max, line at mean). A: inspiratory capacity as % control: *P < 0.001 for negative-control-miR and pre-miR-21 treatment vs. control. B: bronchoalveolar lavage fluid (BALF) protein concentration: *P < 0.001 for control vs. all ventilated mice, #P < 0.05 for anti-miR-21 treatment vs. negative-control-miR and pre-miR-21. C: BALF concentrations of IL-6: *P < 0.001 for control vs. all ventilated mice. D: BALF concentrations of macrophage inflammatory protein (MIP)-2: *P < 0.001 for control vs. all ventilated mice, #P < 0.05 for anti-miR-21 vs. pre-miR-21 treatment.