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siRNA-mediated knockdown of SERCA2 prevents VEGF-induced endothelial cell migration. HAECs were treated with specific siRNA to SERCA2. Knockdown was confirmed by qRT-PCR for SERCA2 (A) and immunoblot for SERCA2 [(B), n=4]. HAECs treated with siRNA for SERCA2 were assessed for basal 45Ca2+ uptake [(C), p<0.001, n=3]. HAEC migration with or without VEGF [(D), 50 ng/ml, n=6]. *p<0.05 versus Control.
