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. 2012 Oct 15;17(8):1053–1065. doi: 10.1089/ars.2012.4518

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Copyright 2012, Mary Ann Liebert, Inc.

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FIG. 5. — Simultaneous overexpression of miR-107 and miR-210 has a stronger pro-survival effect on ^PCMSC survival. (A) Western blot showing the abrogation of PDCD10 and CASP8AP2 in MSC after individual or combined overexpression of miR-107 and miR-210 under lethal anoxia. As compared with ^ScMSC, ¹⁰⁷MSC and ²¹⁰MSC significantly abrogated PDCD10 and CASP8AP2, respectively, under lethal anoxia. On the same note, ^107/210MSC showed the successful simultaneous abrogation of both PDCD10 and CASP8AP2. (B) The TUNEL assay was performed to assess the cytoprotective effects of these molecular events. Although ¹⁰⁷MSC and ²¹⁰MSC were effectively protected against lethal anoxia, ^107/210MSC showed significantly higher survival as compared with ¹⁰⁷MSC and ²¹⁰MSC. (To see this illustration in color the reader is referred to the web version of this article at www.liebertpub.com/ars).