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. Author manuscript; available in PMC: 2012 Aug 21.
Published in final edited form as: Semin Respir Crit Care Med. 2011 Apr 15;32(1):32–43. doi: 10.1055/s-0031-1272867

Table 2.

Published Putative Cancer Stem Cells in Lung Tumorigenesis

Putative Stem Cell (Species) Location/s
in the Lung		 Serial
Xenografting
Performed		 Association with
Prognosis when
Present in Tumors		 References
Bronchoalveolar stem cell (BASC) IF:
 CC10+SPC+FACS:Sca1
 +CD45-Pecam- (mouse)		 Bronchoalveolar duct
 junction		 Yes Not known Kim et al
 (2005)100
Reparative cell IF: K14+K5
 +FACS: N/A (human)		 Submucosal gland duct,
 submucosal glands,
 repairing airway
 epithelium,
 preneoplastic lesions		 No p=0.003 Ooi et al
 (2010)116
CD133+IF and FACS (human) Not known Yes −CD133+Not significant
 for prognosis		 Eramo et al
 (2008)108
−CD133+ABCG2+predicts
 recurrence in stage I
 NSCLC p=0.015		 Bertolini et al
 (2009)110
−Associated with resistance
 to chemotherapy		 Salnikov et al
 (2010)109
Li et al (2010)111
ALDH+ (human) Not known Yes p=0.009 Jiang et al
 (2009)107
−Associated with resistance
 to chemotherapy

ALDH, aldehyde dehydrogenase; K14, keratin 14; K5, keratin 5; CC10, Clara cell secretory protein; SPC, surfactant protein C.

EVOLVING CONCEPTS IN LUNG CARCINOGENESIS/GOMPERTS ET AL 37

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