Table 1.
Molecular alteration | Thyroid cancer | Adrenal cancer | Ovarian cancer |
---|---|---|---|
IGF-IR overexpression | + | + | + |
IR overexpression | + (IR-A) |
? | + (IR-A) |
HRs overexpression | + | ? | ? |
IGFs overexpression | + (IGF-I and IGF-II) |
+ (IGF-II > IGF-I) |
+ (IGF-II > IGF-I) |
IGFs autocrine production | + (IGF-I and IGF-II) |
+ (IGF-II > IGF-I) |
+ (IGF-I and IGF-II) |
IGF-II/IR-A loop activation | + | ? | + |
IGFBPs overexpression | + | + (IGFBP-2, IGFBP-3, IGFBP-6) |
+ (IGFBP-2 > IGFBP-3 > IGFBP-4) |
Relationship with elevated levels of insulin | + | + | + |