Fig. 2.

Concentrations of d4T-TP (μM) in activated PBM cells versus time after a single orally administered d4T dose (•). These concentrations were calculated from in vivo d4T-TP measurements reported in lymphocytes (stimulated and non-stimulated) (Becher et al., 2004). Calculations assumed that d4T is primarily phosphorylated in dividing lymphocytes, and an average 8% dividing fraction of lymphocytes (Mohri et al., 2001). The proportion of dividing lymphocytes was not reported in the study of Becher et al., (2004). Also shown is the predicted curve derived from co-fitting the median plasma pharmacokinetic model (without inter-individual variations) (Panhard et al., 2007) with the intracellular data of Becher et al. (2004).