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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Biochim Biophys Acta. 2012 Apr 17;1817(10):1796–1802. doi: 10.1016/j.bbabio.2012.04.004

Figure 3. FISH Analysis of 2p:12p Translocation Resulting in Deletion of CACNA1C and CACNA2D4.

Figure 3

Green = chromosome 2p probe which marks the translocated region and hence results in three copies, Red = chromosome 12q probe which marks the bottom of chromosome 12, this region is not rearranged. Translocation of the tip of the short arm of chromosome 2 (2p) onto the tip of the short arm of chromosome 12 (12p), replaces a section of the short arm of chromosome 2 (2p) with the transferred end of the short arm of chromosome 12 (12p). Loss of one of the two chromosomal copies of 12p removes 27 genes including CACNA1C and CACNA2D4. Generation of an extra copy of the 2p duplicates 12 genes including SNTG2.