Table 1.

Efforts Required for the Physiome Projects

Scientific: New experimental studies, hypothesis driven, to elicit specific information on which to base the understanding of biological systems. Databases for protein dynamics, biochemical and physiological systems, cell biology, and organism level information. Models integrating the information on proteins, cells and systems and databases of running, documented, validated models. Ontologies: explicit naming systems for anatomy, physiological data, chemical and physical terms

Sociological: Free exchange of scientific information. Open source: information on models, algorithms, hypotheses, tools, data. Standards: ontologies, databases for structures, experimental observations, models in archival and reproducible operational form, Sharing: Total honesty, revealing everything, and transparency.

Political: Support for integrated development and translation into applications Establish and support databases. (structure, material and chemical properties, and experimental data on physiological functions, and the models to capture the essence of the data. Support for multi-institutional collaborations including industry Emphasis on reproducibility in science in general and modeling in particular.