Table 1.
AD | PDAD | PDD | PD | NC | P values | |
---|---|---|---|---|---|---|
N (M:F) | 50 (25:25) | 40 (30:10) | 31(22:9) | 31(18:13) | 62 (33:29) | 0.07 |
age at death-mean (±stdev) | 81±10 | 81±5 | 77±6 | 80±7 | 87±6* | <0.001 |
PD duration-mean (±stdev) | - | 10±6 | 15±8# | 14±8 | - | 0.01 |
Number of cases | - | 37 | 31 | 25 | - | |
Dementia duration-mean (±stdev) | 8±4* | 3±2 | 4±5 | - | - | <0.001 |
Number of cases | 42 | 15 | 13 | - | - | |
Braak NFT stage-median (range) | V (II–VI)* | IV (I–V)** | II (I–IV) | III (I–IV) | III (I–IV) | <0.001 |
NIA Reagan-median | high** | intermediate** | not met | not met | not met | <0.001 |
APOE4 allele, N (%) | 27 (54)** | 17 (43)** | 5 (16) | 6 (19) | 17 (27) | <0.001 |
Unified LB stage, N (%) | ||||||
lla. Brainstem Predominant | - | 3 (8) | 3 (10) | 8 (26) | - | 0.06 |
llb. Limbic Predominant | - | 0 | 1 (3) | 3 (10) | - | 0.12 |
lll. Brainstem/Limbic | - | 13 (33) | 19 (61)# | 16 (52)# | - | <0.001 |
lV. Neocortical | - | 23 (59)┼ | 9 (29) | 4 (13) | - | <0.001 |
significantly greater than all other groups,
significantly greater than PDD, PD, and NC,
significantly greater than PDAD,
significantly greater than PDD and PD.