Table 1.
Demographics and pathologic descriptions of series. AD=Alzheimer’s disease, PDAD= Parkinson’s disease dementia with AD, PDD= Parkinson’s disease dementia without AD, PD= Parkinson’s disease, NC= non-demented normal control, NFT=neurofibrillary tangles, LB=Lewy bodies.
| AD | PDAD | PDD | PD | NC | P values | |
|---|---|---|---|---|---|---|
| N (M:F) | 50 (25:25) | 40 (30:10) | 31(22:9) | 31(18:13) | 62 (33:29) | 0.07 |
| age at death-mean (±stdev) | 81±10 | 81±5 | 77±6 | 80±7 | 87±6* | <0.001 |
| PD duration-mean (±stdev) | - | 10±6 | 15±8# | 14±8 | - | 0.01 |
| Number of cases | - | 37 | 31 | 25 | - | |
| Dementia duration-mean (±stdev) | 8±4* | 3±2 | 4±5 | - | - | <0.001 |
| Number of cases | 42 | 15 | 13 | - | - | |
| Braak NFT stage-median (range) | V (II–VI)* | IV (I–V)** | II (I–IV) | III (I–IV) | III (I–IV) | <0.001 |
| NIA Reagan-median | high** | intermediate** | not met | not met | not met | <0.001 |
| APOE4 allele, N (%) | 27 (54)** | 17 (43)** | 5 (16) | 6 (19) | 17 (27) | <0.001 |
| Unified LB stage, N (%) | ||||||
| lla. Brainstem Predominant | - | 3 (8) | 3 (10) | 8 (26) | - | 0.06 |
| llb. Limbic Predominant | - | 0 | 1 (3) | 3 (10) | - | 0.12 |
| lll. Brainstem/Limbic | - | 13 (33) | 19 (61)# | 16 (52)# | - | <0.001 |
| lV. Neocortical | - | 23 (59)┼ | 9 (29) | 4 (13) | - | <0.001 |
*
significantly greater than all other groups,
**
significantly greater than PDD, PD, and NC,
#
significantly greater than PDAD,
┼
significantly greater than PDD and PD.