Table 2.

Striatal and cortical plaque scores for all groups. All values are the median followed by the range in parentheses. The AD and PDAD groups had significantly higher plaque scores (both for total plaques and neuritic/cored plaques) in all areas analyzed. AD=Alzheimer’s disease, CERAD= consortium to establish a registry for Alzheimer’s disease, PDAD= Parkinson’s disease dementia with AD, PDD= Parkinson’s disease dementia without AD, PD= Parkinson’s disease, NC= non-demented normal control, NP= neuritic/cored plaques.

	AD	PDAD	PDD	PDND	NC	P values
CERAD NP cerebral cortex score	3 (2–3)**	2 (2–3)**	0 (0–3)	0 (0–2)	0 (0–1)	<0.001
Total striatal plaque density	2.75 (0–3)**	1.5 (0–3)**	0 (0–2.5)	0 (0–2.5)	0 (0–3)	<0.001
NP striatal density	0.5 (0–2)*	0.25 (0–2)**	0 (0–0.5)	0 (0–0.5)	0 (0–1)	<0.001
Total cortical plaque density	3 (2–3)*	2.67 (1–3)**	0 (0–2.5)	0.5 (0–3)	1.5 (0–3)	<0.001
NP cortical density	3 (2–3)**	2.5 (1–3)**	1 (0–3)	1 (0–3)	1 (0–3)	<0.001

^*significantly greater than all other groups,

^**significantly greater than PDD, PD, and NC