Area growth of skin for stretch-driven transversely isotropic growth, with , according to equations (69) and (73.2). Photograph of a tissue expander to induce controlled in situ skin growth for defect correction in reconstructive surgery, left, reprinted with permission, Mentor Worldwide LLC [17]. Computational simulation of transversely isotropic area growth, right, predicts area growth in response to controlled mechanical overstretch during tissue expansion [18].