Table 2.
Control |
SNP |
l-NAME |
||||
---|---|---|---|---|---|---|
Sedentary | Trained | Sedentary | Trained | Sedentary | Trained | |
Po2mv(BL), mmHg | 29.2 ± 1.3 | 27.8 ± 1.2 | 38.7 ± 2.3* | 42.9 ± 3.5* | 25.5 ± 1.7† | 26.4 ± 1.5† |
Δ1Po2mv, mmHg | 11.4 ± 1.2 | 10.6 ± 0.8 | 9.3 ± 1.5 | 15.6 ± 3.3‡ | 13.0 ± 1.0 | 13.0 ± 1.2 |
Δ2Po2mv, mmHg | 2.3 ± 0.3 | 2.5 ± 0.3 | 2.3 ± 0.4 | 2.8 ± 1.3 | ||
ΔTotalPo2mv, mmHg | 9.8 ± 1.2 | 8.6 ± 0.8 | 9.3 ± 1.5 | 15.6 ± 3.3*‡ | 11.2 ± 0.9 | 12.1 ± 1.1 |
Po2mv(SS), mmHg | 19.4 ± 1.0 | 19.2 ± 1.5 | 29.4 ± 1.5* | 27.3 ± 1.4* | 14.3 ± 0.8*† | 14.2 ± 0.9*† |
TD1, s | 10.2 ± 0.7 | 10.3 ± 1.6 | 8.3 ± 1.6 | 11.8 ± 3.6 | 6.2 ± 0.5* | 6.5 ± 0.9*† |
TD2, s | 55.1 ± 9.5 | 53.4 ± 12.4 | 55.0 ± 6.8 | 41.3 ± 7.2 | ||
τ2, s | 39.5 ± 7.8 | 32.3 ± 10.1 | 55.5 ± 8.9 | 51.9 ± 18.9 | ||
MRT, s | 18.3 ± 0.9 | 25.5 ± 3.3# | 47.0 ± 5.8* | 38.6 ± 5.2*‡ | 18.1 ± 1.7† | 17.7 ± 1.6† |
Values are means ± SE. Po2mv, microvascular Po2; Po2mv(BL), resting Po2mv; Δ1Po2mv, amplitude of the first component; Δ2Po2mv, amplitude of the second component; ΔTotalPo2mv, overall amplitude regardless of one- or two-component model fit; Po2mv(SS), contracting steady-state Po2mv; TD1, time delay for the first component; TD2, time delay for the second component; τ2, time constant for the second component, MRT, mean response time. The time constant for the first component (τ1) and relative rate of Po2mv fall (Δ1Po2mv /τ1) are shown in Fig. 3. The one-component exponential model was used to analyze the Po2mv kinetics in the following conditions: sedentary control (6/18), sedentary SNP (14/14), sedentary l-NAME (3/14), trained control (2/10), trained SNP (9/9), and trained l-NAME (7/10). Significantly different from:
control within group;
SNP within group;
sedentary within superfusion condition.
P = 0.13 vs. sedentary control.