Table 1.
Extra-digit phenotypes of Gli3+/Xt;Neo1Gt double mutants.
| Limbs with extra digits1 (%) | ||||
|---|---|---|---|---|
| Genotype | Left hindlimb | Right hindlimb | Left forelimb | Right forelimb |
| Gli3+/+;Neo1+/+ (n=3) | 0 | 0 | 0 | 0 |
| Gli3+/+;Neo1+/Gt (n≥8) | 0 | 0 | 0 | 0 |
| Gli3+/+;Neo1Gt/Gt (n≥14) | 0 | 14.3 | 0 | 0 |
| Gli3+/Xt-J;Neo1+/+ (n≥18) | 5.6 | 16.7 | 40.9 | 78.9 |
| Gli3+/Xt-J;Neo1+/Gt (n≥11) | 7.7 | 9.1 | 53.8 | 66.7 |
| Gli3+/Xt-J;Neo1Gt/Gt (n≥22) | 27.3* | 59.1* | 0** | 4.3** |
1
Numbers of digits were counted after bone and cartilage staining of E18.5 embryos.
*
Different from Gli3+/Xt-J;Neo1+/+, p<0.01;
**
different from Gli3+/Xt-J;Neo1+/+, p<0.0001.