Table 1.
Functional GO categories and KEGG pathways enriched with genes that were differentially expressed in response to a combination of PPC and saponins
| GO categories and KEGG pathways | Features* | p-value† |
|---|---|---|
| Inflammatory response |
26/236 |
<0.001 |
| Complement and coagulation cascade |
10/92 |
0.026 |
| Antigen processing and presentation |
9/77 |
0.022 |
| Chemokine activity |
5/6 |
<0.001 |
| Valine, leucine and isoleucine degradation |
17/79 |
<0.001 |
| Arginine and proline metabolism |
14/107 |
<0.001 |
| Tryptophan metabolism |
12/60 |
<0.001 |
| Tyrosine metabolism |
10/51 |
<0.001 |
| Glycine, serine and threonine metabolism |
10/56 |
<0.001 |
| Lysine degradation |
8/57 |
0.009 |
| Beta-alanine metabolism |
6/41 |
0.022 |
| Lipid metabolic process |
27/300 |
0.004 |
| Retinol metabolism |
18/79 |
<0.001 |
| Fatty acid metabolic process |
14/97 |
<0.001 |
| Glycerolipid metabolism |
13/68 |
<0.001 |
| C21-steroid hormone metabolism |
8/49 |
0.002 |
| Sphingolipid metabolism |
7/51 |
0.018 |
| Carbohydrate metabolic process |
22/264 |
0.023 |
| Mitochondrion |
78/1091 |
0.002 |
| Lysosome |
20/183 |
<0.001 |
| Protein folding |
19/180 |
0.002 |
| Peroxisome |
16/118 |
<0.001 |
| Cell surface |
15/136 |
0.004 |
| Metabolism of xenobiotics |
12/55 |
<0.001 |
| Glutathione metabolism |
12/69 |
<0.001 |
| Glycosaminoglycan degradation |
5/32 |
0.031 |
| Extracellular space |
28/367 |
0.032 |
| Basement membrane |
9/68 |
0.008 |
| Hormone activity |
8/41 |
<0.001 |
| Digestion | 7/49 | 0.014 |
* Numbers of genes among DEG and on the microarray platform.
† Yates’ corrected chi-square.