Table 3.
Protein–protein interaction in gene network
| Functional proteins | Score | Potential functions |
|---|---|---|
| gyrA | 0.999 | DNA gyrase, A subunit |
| dnaN | 0.995 | DNA polymerase III, beta subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria |
| parC | 0.990 | DNA topoisomerase IV |
| recF | 0.987 | DNA replication and repair protein RecF; The recF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility |
| dnaA | 0.977 | Chromosomal replication initiation protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication |
| rpoD | 0.875 | RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released |
| rpoB | 0.741 | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates |
| dnaJ | 0.738 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion |
| mnmE | 0.726 | tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 |
| rpmH | 0.706 | 50S ribosomal protein L34 |