Table 3. Adverse events between more intensive and less intensive BP lowering regimen.

Adverse Event	Study	Participants	Events Rate* (More/Less Intensive)	RR (95% CI)	p-Value
Total Severe AEs [16]–[18],[30],[33]	5	9,827	309 (1.7)/255(1.4)	1.19 (0.88–1.61)	0.250
Total AEs [17],[18],[33],[36]	4	9,174	934 (8.4)/943 (8.5)	0.99 (0.92–1.08)	0.844
Discontinue medication [16],[17],[32],[33]	4	9,874	179 (1.1)/161 (1.0)	0.96 (0.79–1.16)	0.663
Total AEs associated with BP medication
Hypotension [16],[17],[29],[33]	4	14,138	76 (0.4)/16 (0.08)	4.16 (2.25–7.70)	<0.001
Dizziness [16],[17],[33]	3	6,229	220 (1.7)/193 (1.5)	1.15 (0.95–1.38)	0.148
Angioedema [16],[17]	2	5,844	7 (0.06)/5 (0.04)	1.40 (0.44–4.42)	0.565
Cough [17],[33]	2	1,496	14 (0.7)/11 (0.5)	0.67 (0.04–10.91)	0.775
Hyperkalemia [16],[33]	2	5,118	84 (0.7)/86 (0.7)	0.98 (0.73–1.32)	0.917
Severe AEs associated with BP medication
Hypotension [16],[33]	2	5,118	17 (0.14)/3 (0.02)	2.19 (0.03–164.77)	0.723
Hyperkalemia [16],[33]	2	5,118	12 (0.1)/5 (0.04)	2.39 (0.20–28.59)	0.490
Renal failure [16],[33]	2	5,118	35 (0.3)/40 (0.3)	1.47 (0.26–8.23)	0.658
Angioedema [16]	1	4,733	6 (0.05)/4 (0.04)	1. 51 (0.43–5.33)	0.548
Syncope [16]	1	4,733	12 (0.1)/5 (0.04)	2.41 (0.85–6. 83)	0.088
Arrhythmia [16]	1	4,733	12 (0.1)/3 (0.03)	4.02 (1.13–14.21)	0.020