Cross-sectional z scores of height-adjusted maximal expiratory flows at ages 2.4 mo, 6, 11 and 16 years for the preschool wheezing groups in the Tucson Children’s Respiratory Study. The z score indicates how many standard deviations from the mean an individual’s value lies. This figure illustrates that those with persistent wheezing begin life with flows that do not differ from their peers with late-onset wheeze or those who never wheeze, but by age 6 demonstrate decrements in flow relative to these other groups. In contrast, those with transient early wheezing demonstrate early and persistent reductions in flow. Taken from Morgan WJ, Stern DA, Sherrill DL, Guerra S, Holberg CJ, Guilbert TW, et al. Outcome of asthma and wheezing in the first 6 years of life. Follow-up through adolescence. Am J Respir Crit Care Med 2005;172:1253–8 (28). Official Journal of the American Thoracic Society. Reprinted with permission of the American Thoracic Society. Copyright (C) 2005 American Thoracic Society.