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. Author manuscript; available in PMC: 2012 Sep 23.
Published in final edited form as: Immunity. 2011 Aug 11;35(3):388–399. doi: 10.1016/j.immuni.2011.07.007

Figure 2. Impaired CHS Response to Oxazolone in the Absence of Eps8.

Figure 2

(A) Eps8 deficiency significantly impairs ear swelling upon OXA sensitization. WT (Eps8+/+) and Eps8−/− (Eps8−/−) mice sensitized with OXA on day 0, were challenged after 5 days on the right ear with OXA. Ear thickness was measured from 24 hr to 96 hr after challenge. Data represent the mean swelling values of 5 mice/group of three independent experiments. **p < 0.01; *p < 0.05.

(B) Cellular infiltrate and edema are reduced in Eps8-deficient mice 48 hr after OXA challenge. Histological analysis of the CHS response: WT (Eps8+/+, left panels) and Eps8-deficient (Eps8−/−, right panels) mice ears, unchallenged (top) or 48 hr after OXA challenge (bottom). The scale bar represents 200 µm.

(C) WT (Eps8+/+, black circle) and Eps8-deficient mice (Eps8−/−, open circle) immunized with WT or Eps8-deficient OVA-loaded BMDCs cells were challenged with OVA in the right footpad and vehicle in the left footpad. Data represent the mean swelling values of 5 mice/group of two independent experiments. **p < 0.01; *p < 0.05.