Table 1.

Patient Clinical Characteristics by Genotype and Smoking History

	EGFR mutation			KRAS mutation			ALK rearrangement			Uncharacterized
	Never smoker	Former/current smoker	p	Never smoker	Former/current smoker	p	Never smoker	Former/current smoker	p	Never smoker	Former/current smoker	p
Characteristic
Total Patients	110 (38%)	54 (14%)	<0.001	14 (5%)	157 (41%)	<0.001	35 (12%)	9 (2%)	<0.001	134 (46%)	162 (43%)
Age
Median	63	68	0.38	63	66	0.27	57	71	0.10	66	66	0.24
Range	39–88	45–86		31–78	40–86		32–84	42–84		39–89	33–86
≥70	38 (35%)	24 (44%)		3 (21%)	55 (35%)		9 (26%)	5 (56%)		49 (37%)	50 (31%)
KPS
Median	90	80	0.95	80	80	0.71	80	80	0.4	90	80	0.04
Range	60–90	60–90		60–90	50–90		60–90	80–90		60–90	30–90
≤70	11 (16%)	5 (15%)		0	27 (25%)		5 (14%)	0		18 (20%)	31 (27%)
Pack-years smoked
Median		18			32			15			31
Range		1–90			1–150			1–60			1–150
Gender
Women (%)	77 (70%)	39 (74%)	0.71	11 (92%)	110 (70%)	0.18	18 (51%)	4 (44%)	1.0	104 (73%)	82 (50%)	0.16
Stage
I–IIIA	42 (38%)	20 (37%)	0.20	4 (29%)	50 (32%)	0.12	5 (14%)	1 (11%)	0.42	45 (36%)	48 (30%)	0.82
IIIB/IV	68 (62%)	34 (63%)		10 (71%)	107 (68%)		30 (86%)	8 (89%)		89 (64%)	114 (70%)
Ethnicity
White	87 (79%)	47 (87%)	0.54	10 (71%)	144 (92%)	0.38	26 (74%)	8 (89%)	0.29	116 (87%)	141 (87%)	0.89