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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: J Immunol. 2012 Jul 23;189(5):2151–2158. doi: 10.4049/jimmunol.1103741

Figure 4.

Figure 4

mTOR inhibition affects activation-induced metabolic changes in mouse but not human DCs. (A) Mouse BMDCs were either left unstimulated, or treated with LPS in the presence or absence of rapamycin or KU as indicated and supernatants collected 48 hours later for analysis of glucose concentration (left) and lactate concentration (right). (B) Human myeloid DCs were either left unstimulated, or treated with R848 in the presence or absence of rapamycin or KU as indicated and supernatants collected 48 hours later for analysis of glucose concentration (left) and lactate concentration (right). Asterisks indicate statistically significant differences between groups (p<0.05). For all graphs data represent the mean +/− SD of data from at least 3 individual mice or donors.