Table 2.

The effect of minocycline alone on core temperature, thermal and mechanical withdrawal threshold.

	Day 0 (prior to i.p. minocycline)		Day 2 (after i.p. minocycline)
Measure	Vehicle	Minocycline	Vehicle	Minocycline
Core temperature (°C)	37.56 ± 0.08	37.58 ± 0.06	37.50 ± 0.08	37.46 ± 0.07
Thermal threshold (sec)	9.13 ± 0.50	10.11 ± 0.71	9.53 ± 0.52	10.19 ± 0.58
Mechanical threshold (g)	17.64 ± 1.59	19.17 ± 1.17	17.82 ± 1.42	20.13 ± 1.17

Either the vehicle (saline, N=14) or minocycline (25 mg/kg, N=12) was treated for 3 consecutive days (Day 0, 1 and 2, once a day). On Day 0 (before minocycline injection) and Day 2 (after minocycline injection), core temperature and withdrawal thresholds were measured to examine the effect of minocycline itself prior to LPS injection. Data were expressed by means ± SEM.