Skip to main content
. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Alcohol Clin Exp Res. 2012 Apr 6;36(10):1678–1687. doi: 10.1111/j.1530-0277.2012.01792.x

Figure 3. Acute Alcohol Attenuation of NMDA Response is Not Observed After 7-Days of Alcohol Exposure.

Figure 3

Whole-cell patch clamp recordings from neurons derived from a non-alcohol dependent subject. (A) Example of the time course illustrating the inhibition of the NMDA response by acute alcohol exposure (50 mM) in a naïve neuron. (B) Example of the lack of effect of alcohol on NMDA receptors following 7-day exposure to 50 mM alcohol. (C) Group data for the effect of acute alcohol which significantly reduced the amplitude of the NMDA response (n=8, paired t-test, p= .036). (D) Group data for 7-day alcohol pre-treated cells showing no significant effect of bath applied alcohol on NMDA response (n=10, paired t-test, p= .77). Differences in the mean amplitude of the baseline depolarization between naïve and chronically treated cells (panels C and D) relate in large measure to variation in the distance of the puffing pipette from the patched cells examined.