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. Author manuscript; available in PMC: 2013 Aug 21.
Published in final edited form as: Anal Chem. 2012 Aug 2;84(16):7256–7262. doi: 10.1021/ac301749h

Figure 1.

Figure 1

Scanning electron microscopy images of POROS AL particles before (A) and after pressurization (B). The control did not experience any pressure prior to the SEM image while 3,600, and 24,000 psi were applied in the middle and right panels. For the 24,000 psi experiment, two different fields of particles are shown. (B) POROS particle strength in normalized flow vs. pressure. The results for POROS particles begin to deviate from the theoretical value assuming no particle destruction around 8,000 psi. (C) Scheme for pepsin immobilization onto BEH particles. Note that in the attachment of the triethoxysilyl butyraldehyde to pepsin, only the final product is shown. The chemistry involving the aldehyde reaction with the amines in pepsin, Schiff base formation and subsequent reduction are not show in the diagram but are explained in the Experimental Section.