Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2014 May 1.

Published in final edited form as: J Surg Res. 2012 May 8;181(1):32–40. doi: 10.1016/j.jss.2012.04.038

A comparison of the effect of pluronic gel with and without GP-2A, siRNA to Gαq or adenovirus with dominant negative Gαq on intimal hyperplasia development at 14 days after wire injury (A). Changes in the area of cells, collagen, proteogylcan and elastin in wire-injured femoral vessels in the presence of pluronic gel with and without GP-2A, siRNA to Gαq or adenovirus with dominant negative Gαq (B). The percent area of the wall composed of proteoglycans increased significantly after wire injury (p<0.05) and this increase was decreased by transfection with Gαq, with a significant increase in collagen deposition (p<0.05). Values are the mean± s.e.m. (n=6 per group). Statistical differences between groups were tested with a Kruskal-Wallis non-parametric test with post hoc Dunn’s multiple comparison correction, where appropriate.

A comparison of the effect of pluronic gel with and without GP-2A, siRNA to Gαq or adenovirus with dominant negative Gαq on intimal hyperplasia development at 14 days after wire injury (A). Changes in the area of cells, collagen, proteogylcan and elastin in wire-injured femoral vessels in the presence of pluronic gel with and without GP-2A, siRNA to Gαq or adenovirus with dominant negative Gαq (B). The percent area of the wall composed of proteoglycans increased significantly after wire injury (p<0.05) and this increase was decreased by transfection with Gαq, with a significant increase in collagen deposition (p<0.05). Values are the mean± s.e.m. (n=6 per group). Statistical differences between groups were tested with a Kruskal-Wallis non-parametric test with post hoc Dunn’s multiple comparison correction, where appropriate.