Table 1.

List of potential predictors included in development of the risk score for serious infections

Stage of development process	List of potential predictors considered
Predictors included in Doran model of serious infections	Age, sex, alcoholism, history of leukopenia, dementia/Alzheimer’s disease, diabetes mellitus, chronic lung disease, extraarticular manifestations of RA (including amyloidosis, Felty’s syndrome, rheumatoid vasculitis and rheumatoid lung disease), rheumatoid factor, functional capacity, corticosteroid use and the interaction between age and diabetes mellitus
Additional predictors included in Doran model of objectively confirmed infections	Erythrocyte sedimentation rate, rheumatoid nodules
Other predictors considered by Doran	Smoking status, body mass index, and disease modifying-anti-rheumatic medications (methotrexate, azathioprine, hydroxychloroquine, sulfasalazine, intramuscular gold, oral gold, D-penicillamine, leflunomide, and cyclophosphamide)
Additional predictors considering in the original cohort	Coronary heart disease, heart failure, peripheral vascular disease, presence of large joint swelling, presence of erosions/destructive changes on radiographs, joint surgeries, RA disease duration, calendar year, and previous serious infections
Additional predictors considered in the validation cohort	Leukocytes, lymphocytes, neutrophils, C-reactive protein and biologic agents