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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Gene Ther. 2012 May 3;20(3):274–282. doi: 10.1038/gt.2012.38

Figure 1. Diagram of the rAAVU7 smOPT E6E8 vector genome.

Figure 1

The 1303 nt single-stranded rAAVU7smOPT E6E8 vector genome is represented schematically. The AAV type 2-derived ITRs are represented by rectangles with diagonal slashes. The two U7smOPT expression cassettes are identical except for the short anti-sense sequences complementary to the exon 6 and exon 8 exon splice enhancers (ESE) of the canine dystrophin gene (vertical and horizontal slashes, respectively). Sequences homologous to the non-coding murine U7 snRNA are represented by rectangles labeled “U7” and the positions of the smOPT modification are indicated.