Table 4.
Results of the Prometheus IBD sgi Diagnostic Test
| Serology results | ||
|---|---|---|
| Marker | Result | Reference |
| ASCA IgA | >100.0 EU/mL | <8.5 EU/mL |
| ASCA IgG | 74.4 EU/mL | <17.8 EU/mL |
| Anti-OmpC IgA | <3.1 EU/mL | <10.9 EU/mL |
| Anti-CBir1 IgG | 19.7 EU/mL | <78.4 EU/mL |
| Anti—A4-Fla2 IgG | 23.9 EU/mL | <44.8 EU/mL |
| Anti-FlaX IgG | 29.8 EU/mL | <33.4 EU/mL |
| IBD-specific pANCA | ||
| Autoantibody | 11.7 EU/mL | <19.8 EU/mL |
| IFA perinuclear pattern | ND | ND |
| DNAse sensitivity | ND | ND |
| Genetics results | ||
|---|---|---|
| Marker | Result | Reference |
| ATG16L1 SNP (rs2241880) | Homozygous G/G mutation detected | No mutation detected |
| ECM1 SNP (rs3737240) | Heterozygous C/T mutation detected | No mutation detected |
| NKX2-3 SNP (rs10883365) | Heterozygous A/G mutation detected | No mutation detected |
| STAT3 SNP (rs744166) | Mutation detected | Mutation detected |
| Inflammation results | ||
|---|---|---|
| Marker | Result | Reference |
| ICAM-1 | 0.39 µg/mL | <0.54 µg/mL |
| VCAM-1 | 0.55 µg/mL | <0.68 µg/mL |
| VEGF | 182 pg/mL | <345 pg/mL |
| CRP | 28.2 mg/L | <13.2 mg/L |
| SAA | >181.6 mg/L | <10.9 mg/L |
ASCA=anti—Saccharomyces cerevisiae antibody; CBir1=flagellin; CRP=C-reactive protein; EU/mL=endotoxin units per milliliter; IBD=inflammatory bowel disease; ICAM-1=intercellular adhesion molecule 1; IFA=indirect fluorescent antibody assay; Ig=immunoglobulin; ND=not detected; OmpC=outer membrane protein C; pANCA=perinuclear antineutrophil cytoplasmic antibody; SAA=serum amyloid A; SNP=single nucleotide polymorphism; VCAM-1=vascular cell adhesion molecule 1; VEGF=vascular endothelial growth factor.