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. 2012 Mar 15;5(5):627–635. doi: 10.1242/dmm.009407

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© 2012. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 3. — Increased renal inflammation and STAT3 signaling in DIO rats. (A-H) Relative gene expression levels normalized to the geometric average of the respective housekeeping gene hypoxanthine guanine phosphoribosyl transferase 1 (HPRT1). (A) Interleukin 6 (IL-6), (B) interleukin 1β (IL-1β), (C) tumor necrosis factor-α (TNF), (D) interleukin 6 receptor (IL6-R), (E) leptin receptor (Lep-R), (F) suppressor of cytokine signaling 3 (SOCS3), (G) monocyte chemotactic protein-1 (MCP-1), (H) plasminogen activator inhibitor-1 (PAI-1). (I) Representative western blot (n=3–4) and densitometric analysis (n=7–8) of phosphorylated STAT3 (p-STAT3) and total STAT (t-STAT3). The ratio of p-STAT3 to t-STAT3 from DIOres and DIOsens rats was normalized to the ratio derived from chow-fed controls (defined as onefold change). All values are given as means ± s.e.m. Significant differences were analyzed by using one-way ANOVA and Bonferroni multiple comparison post tests and indicated as *P<0.05 and ***P<0.001 vs chow controls.