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. 2012 Jul 5;5(5):636–648. doi: 10.1242/dmm.009266

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© 2012. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 2. — Ultrastructural changes in the glomeruli of the POKO mice. (A) Transmission electron microscopy of glomeruli of 4-week-old POKO mice with broadening of foot processes (arrows). Foot processes in POKO mice are completely lost by 12 weeks (arrows). Original magnification: 20,000×. (B) GBM thickening in POKO mice when measuring the lamina densa (n=3–4). GBM thicknesses (white star in A) were measured across the whole GBM and across the lamina densa. Data are means±s.e.m.; n=6 in each group; ***P<0.001 POKO vs ob/ob; ^#P<0.05, ^###P<0.001 POKO vs WT; ^$$P<0.01, ^$$$P<0.001 ob/ob vs WT.