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. 2012 Jul 5;5(5):636–648. doi: 10.1242/dmm.009266

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© 2012. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 3. — Insulin resistance in POKO kidneys. (A) Total kidney mRNA levels of glucose metabolism genes from 4-week-old male WT, PPARγ2 KO, ob/ob and POKO mice. Data are means±s.e.m.; n=8–9. *P<0.05 POKO vs ob/ob; ^#P<0.05 POKO vs WT; ^$P<0.05 ob/ob vs WT; ^ϕP<0.05 PPARγ2 KO vs WT. Normalized levels with BestKeeper (Bk). (B) Representative immunoblot for pAKT(Ser473) from WT, ob/ob and POKO 4-week-old-male mice treated and non treated with insulin. Levels were normalized to total protein kinase B (AKTt). Each value is the relative optical intensity of each band normalized as a percentage of the saline-treated group. Values are represented in graphic (n=5–8). Data are means±s.e.m. *P<0.05 WT saline vs WT insulin. G6Pase, glucose 6-phosphatase; PEPCK, phosphoenolpyruvate carboxykinase; IRS, insulin receptor substrate.