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. 2012 Jul 5;5(5):636–648. doi: 10.1242/dmm.009266

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© 2012. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 4. — Altered lipid metabolism in POKO kidneys. (A) Representative Oil-Red-O staining in the kidney from WT, PPARγ2 KO, ob/ob and POKO mice at 4 weeks. Original magnification: 400× (n=4). (B) Intraglomerular electron micrographs of ob/ob mice (12,000×) and POKO mice (15,000×) showing accumulation of lipid droplets (arrows). (C) Total kidney mRNA levels of lipid metabolism genes from 4-week-old male WT, PPARγ2 KO, ob/ob and POKO mice. Data are means±s.e.m.; n=8–9. *P<0.05, **P<0.01, ***P<0.001 POKO vs ob/ob; ^#P<0.05 POKO vs WT; ^ϕP<0.05 PPARγ2 KO vs WT. Normalized levels with BestKeeper (Bk).